Adamts10 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to be located in collagen-containing extracellular matrix and microfibril. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Orthologous to human ADAMTS10 (ADAM metallopeptidase with thrombospondin type 1 motif 10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adamts10 |
| Official Name | ADAM metallopeptidase with thrombospondin type 1 motif, 10 [Source:RGD Symbol;Acc:1598320] |
| Ensembl ID | ENSRNOG00000008857 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase with thrombospondin type 1 motif, 10 |
| Synonyms | 9430006O18, ADAM metallopeptidase with thrombospondin type 1 motif 10, ADAM metallopeptidase with thrombospondin type 1 motif, 10, LOC148230, WMS, WMS1, Znmp |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adamts10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Reprolysin family propeptide
- ADAMTS cysteine-rich domain 2
- ADAMTS cysteine-rich domain
- peptidase
- PLAC (protease and lacunin) domain
- protein binding
- ADAM-TS Spacer 1
- ZnMc
- Metallo-peptidase family M12B Reprolysin-like
- Reprolysin (M12B) family zinc metalloprotease
- Spondin-like TSP1 domain
Pathways
Biological processes and signaling networks where the Adamts10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- Weill-Marchesani syndrome 1
- Weill-Marchesani syndrome
- carpal tunnel syndrome
- androgenic alopecia
- osteoarthritis
- abdominal aortic aneurysm
regulates
role in cell
- biogenesis in
- biogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Plasma Membrane
- microfibrils
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adamts10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- extracellular matrix organization
Cellular Component
Where in the cell the gene product is active
- microfibril
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- metalloendopeptidase activity