Chchd3 Gene Summary [Rat]
Predicted to enable molecular adaptor activity and phosphatase binding activity. Predicted to be involved in cristae formation and mitochondrial fusion. Predicted to be located in mitochondrial inner membrane. Predicted to be part of MICOS complex. Orthologous to human CHCHD3 (coiled-coil-helix-coiled-coil-helix domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chchd3 |
| Official Name | coiled-coil-helix-coiled-coil-helix domain containing 3 [Source:RGD Symbol;Acc:1310325] |
| Ensembl ID | ENSRNOG00000013211 |
| Bio databases IDs | |
| Aliases | coiled-coil-helix-coiled-coil-helix domain containing 3 |
| Synonyms | 0610041L09RIK, 1700039J09Rik, CHCH3, coiled-coil-helix-coiled-coil-helix domain containing 3, Mic19, MICOS19, MINOS3, PPP1R22 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chchd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MICOS complex subunit MIC19/MIC25
- transcription regulator
- CHCH domain
- protein binding
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- hepatic steatosis
- hepatic fibrosis
role in cell
- expression in
- formation
- number
- fusion
- homologous recombination in
- disorganization
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chchd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cristae formation
- mitochondrial fusion
- inner mitochondrial membrane organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- mitochondrial crista junction
- mitochondrion
- mitochondrial sorting and assembly machinery complex
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- protein binding
- binding, bridging