RGD1359108 Gene Summary [Rat]
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including axon extension; regulation of organelle organization; and stress granule assembly. Predicted to be located in several cellular components, including Flemming body; axon; and cytoplasmic ribonucleoprotein granule. Predicted to be part of Atg1/ULK1 kinase complex and guanyl-nucleotide exchange factor complex. Predicted to be active in several cellular components, including autophagosome; hippocampal mossy fiber to CA3 synapse; and presynaptic cytosol. Human ortholog(s) of this gene implicated in frontotemporal dementia and/or amyotrophic lateral sclerosis 1. Orthologous to human C9orf72 (C9orf72-SMCR8 complex subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | RGD1359108 |
| Official Name | similar to RIKEN cDNA 3110043O21 [Source:RGD Symbol;Acc:1359108] |
| Ensembl ID | ENSRNOG00000009478 |
| Bio databases IDs | |
| Aliases | similar to RIKEN cDNA 3110043O21 |
| Synonyms | 3110043O21Rik, ALSFTD, C9orf72, member of C9orf72-SMCR8 complex, C9orf72-SMCR8 complex subunit, DENND9, DENNL72, FLJ11109, FTDALS, FTDALS1, RGD1359108, similar to RIKEN cDNA 3110043O21 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rgd1359108 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C9orf72-like protein family
- guanyl-nucleotide exchange factor
- Gly-Ala repeat
- enzyme binding
- GTPase activator
- protein binding
Pathways
Biological processes and signaling networks where the Rgd1359108 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sporadic amyotrophic lateral sclerosis
- amyotrophic lateral sclerosis
- frontotemporal dementia and/or amyotrophic lateral sclerosis type 1
- poor social function
- mood disorder
- susceptibility to amyotrophic lateral sclerosis
- familial amyotrophic lateral sclerosis
role in cell
- cell death
- quantity
- expression in
- phosphorylation in
- autophagy by
- number
- extension
- survival
- morphology
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- axon component
- intracellular membrane-bounded organelle
- cytoplasmic mRNA processing body
- presynaptic regions
- Extracellular Space
- postsynaptic region
- Nucleus
- endosomes
- lysosome
- Flemming body
- cytosol
- nuclear envelope
- neurites
- synapse
- autophagic vacuoles
- stress granule
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rgd1359108 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macroautophagy
- stress granule assembly
- axon extension
- regulation of protein localization
- autophagy
- negative regulation of protein phosphorylation
- regulation of autophagy
- regulation of autophagic vacuole assembly
- endocytosis
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- cytoplasmic mRNA processing body
- main axon
- perikaryon
- autophagic vacuole
- lysosome
- dendrite
- nucleus
- extracellular space
- nuclear membrane
- endosome
- axonal growth cone
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- guanyl-nucleotide exchange factor complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding