Pex12 Gene Summary [Rat]
Predicted to enable ubiquitin ligase activator activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Involved in peroxisome organization. Located in peroxisome. Is active in peroxisomal membrane. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 3A and peroxisome biogenesis disorder 3B. Orthologous to human PEX12 (peroxisomal biogenesis factor 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pex12 |
| Official Name | peroxisomal biogenesis factor 12 [Source:RGD Symbol;Acc:620757] |
| Ensembl ID | ENSRNOG00000009718 |
| Bio databases IDs | |
| Aliases | peroxisomal biogenesis factor 12 |
| Synonyms | LOC100909787, LOC108348326, LT629148.7, LT629151.7, LT629154.11, PAF-3, PBD3A, Peroxin-12, peroxisomal biogenesis factor 12, Pex12p |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pex12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein carrier
- zinc ion binding
- Pex2 / Pex12 amino terminal region
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- protein binding
- enzyme regulator activity
- enzyme activator activity
- zinc binding domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peroxisome biogenesis disorder 3a (Zellweger)
- Zellweger syndrome
- hereditary disorder
- infantile refsum disease
- peroxisome biogenesis disorder complementation group 3
- peroxisome biogenesis disorder
- peroxisomal biogenesis disorder 3B
regulated by
- PEX19
- NUPR1
role in cell
- binding
- restoration
- organization
- response by
- import in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pex12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into peroxisome matrix
- proteasomal ubiquitin-dependent protein catabolic process
- misfolded or incompletely synthesized protein catabolic process
- protein targeting to peroxisome
- protein polyubiquitination
- peroxisome organization
- protein import into peroxisome matrix, receptor recycling
- protein monoubiquitination
- cellular response to reactive oxygen species
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- protein transmembrane transporter activity