Acsl5 Gene Summary [Rat]
Enables arachidonate-CoA ligase activity. Involved in several processes, including organophosphate biosynthetic process; positive regulation of lipid metabolic process; and positive regulation of long-chain fatty acid import across plasma membrane. Predicted to be located in nucleolus; nucleoplasm; and plasma membrane. Predicted to be active in endoplasmic reticulum; membrane; and mitochondrion. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human ACSL5 (acyl-CoA synthetase long chain family member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acsl5 |
| Official Name | acyl-CoA synthetase long-chain family member 5 [Source:RGD Symbol;Acc:69402] |
| Ensembl ID | ENSRNOG00000016265 |
| Bio databases IDs | |
| Aliases | acyl-CoA synthetase long-chain family member 5 |
| Synonyms | 1700030F05Rik, ACS2, ACS5, Acyl CoA Synthetase 5, acyl-CoA synthetase long-chain family member 5, DIAR13, FACL5, Fatty Acid Coenzyme A Ligase, Long Chain5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acsl5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- long-chain-fatty-acid-CoA ligase
- arachidonate-CoA ligase
- AMP-binding enzyme
- Adenylate forming domain, Class I superfamily
- O-succinylbenzoate-CoA ligase
- enzyme
- protein binding
- amino acid adenylation domain
Pathways
Biological processes and signaling networks where the Acsl5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- systemic lupus erythematosus
- thrombocytopenia
- diarrhea type 13
- androgenic alopecia
- amyotrophic lateral sclerosis
- endometriosis
- pervasive developmental disorder
role in cell
- survival
- expression in
- growth
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- microsome
- mitochondrial membrane
- mitochondria-associated membranes
- mitochondrial outer membrane
- peroxisome membrane
- nucleoplasm
- nucleoli
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acsl5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid metabolic process
- positive regulation of plasma membrane long-chain fatty acid transport
- long-chain fatty-acyl-CoA biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- mitochondrion
- endoplasmic reticulum
- mitochondrial outer membrane
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- arachidonate-CoA ligase activity
- long-chain fatty acid-CoA ligase activity