Grip2 Gene Summary [Rat]
Enables glutamate receptor binding activity. Involved in positive regulation of AMPA glutamate receptor clustering; positive regulation of excitatory postsynaptic potential; and positive regulation of neuron maturation. Located in several cellular components, including dendritic shaft; neuronal cell body; and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human GRIP2 (glutamate receptor interacting protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grip2 |
| Official Name | glutamate receptor interacting protein 2 [Source:RGD Symbol;Acc:621668] |
| Ensembl ID | ENSRNOG00000009726 |
| Bio databases IDs | |
| Aliases | glutamate receptor interacting protein 2 |
| Synonyms | ABP, Abpl, glutamate receptor interacting protein 2, KIAA1719 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Grip2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- LXXLL motif
- canonical PDZ domain
- linker domain
- protein binding
- receptor binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- breast carcinoma
- ischemic stroke
- syndactyly
- cryptophthalmos
role in cell
- maturation
- clustering in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- postsynaptic density (PSD) fractions
- synaptosomal membrane fractions
- glutaminergic synapse
- organelle
- Cytoplasm
- cell surface
- cellular membrane
- cytoplasmic aggregates
- cytosol
- postsynaptic membrane
- dendritic spines
- neurites
- synaptosomes
- synapse
- perikaryon
- dendrites
- postsynaptic density
- dendritic shafts
- synaptosomal fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Grip2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Notch signaling pathway
- artery smooth muscle contraction
- positive regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- dendrite
- neuron spine
- postsynaptic membrane
- cytosol
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- glutamate receptor binding