Gpx7 Gene Summary [Rat]
Predicted to enable catalase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Barrett's adenocarcinoma and Barrett's esophagus. Orthologous to human GPX7 (glutathione peroxidase 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpx7 |
| Official Name | glutathione peroxidase 7 [Source:RGD Symbol;Acc:1306999] |
| Ensembl ID | ENSRNOG00000009751 |
| Bio databases IDs | |
| Aliases | glutathione peroxidase 7 |
| Synonyms | 3110050F08RIK, CL683, glutathione peroxidase 7, GPX6, GSHPx-7, NPGPX |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gpx7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peroxidase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- AhpC/TSA family
- enzyme
- protein binding
- catalase
Pathways
Biological processes and signaling networks where the Gpx7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- non-small cell lung cancer
- neoplasia
- breast cancer
- breast carcinoma
- breast or ovarian cancer
- epithelial cancer
- urogenital cancer
- epithelial neoplasia
- cancer
regulates
- reactive oxygen species
- HSPA5
- luciferase
role in cell
- apoptosis
- cell death
- response by
- sensitivity
- misfolding in
- oxidative stress response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Extracellular Space
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gpx7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to oxidative stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- endoplasmic reticulum
- extracellular region
Molecular Function
What the gene product does at the molecular level
- peroxidase activity
- protein binding
- glutathione peroxidase activity
- catalase activity