Get3 Gene Summary [Rat]
Predicted to enable ATP hydrolysis activity and membrane insertase activity. Involved in tail-anchored membrane protein insertion into ER membrane. Part of GET complex. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human GET3 (guided entry of tail-anchored proteins factor 3, ATPase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Get3 |
| Official Name | guided entry of tail-anchored proteins factor 3, ATPase [Source:RGD Symbol;Acc:1307906] |
| Ensembl ID | ENSRNOG00000003747 |
| Bio databases IDs | |
| Aliases | guided entry of tail-anchored proteins factor 3, ATPase |
| Synonyms | 1810048H22Rik, ArsA, ARSA1, ARSA-I, ASNA1, ASNA-I, CMD2H, guided entry of tail-anchored proteins factor 3, ATPase, TRC40 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Get3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transport-energizing ATPase, TRC40/GET3/ArsA family
- arsenite transporter
- protein binding
- ATPase
- P-loop containing Nucleoside Triphosphate Hydrolases
- Anion-transporting ATPase
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- endoplasmic reticulum membrane
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Get3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tail-anchored membrane protein insertion into ER membrane
- protein insertion into ER membrane
- arsenite transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- GET complex
- extracellular vesicular exosome
- cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- membrane insertase activity
- protein binding
- metal ion binding
- arsenite transmembrane transporter activity