Fam161a Gene Summary [Rat]
Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be involved in cilium assembly and positive regulation of protein acetylation. Located in ciliary basal body and photoreceptor connecting cilium. Human ortholog(s) of this gene implicated in retinitis pigmentosa 28. Orthologous to human FAM161A (FAM161 centrosomal protein A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fam161a |
| Official Name | FAM161 centrosomal protein A [Source:RGD Symbol;Acc:1304999] |
| Ensembl ID | ENSRNOG00000009881 |
| Bio databases IDs | |
| Aliases | FAM161 centrosomal protein A |
| Synonyms | 4930430E16Rik, FAM161 centrosomal protein A, family with sequence similarity 161, member A, RGD1304999, RP28 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fam161a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Uncharacterized protein family UPF0564
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- non-motile cilium
- basal bodies
- centrosome
- Golgi Apparatus
- centriole
- cytosol
- connecting cilia
- nucleoplasm
- spindle pole
- spindle fibers
- neurites
- photoreceptor inner segments
- astral microtubules
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fam161a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- visual perception
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- spindle microtubule
- centrosome
- mitotic spindle
- cilium basal body
- cilium
- photoreceptor inner segment
- astral microtubule
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- microtubule binding