FAM161A Gene Summary [Human]
This gene belongs to the FAM161 family. It is expressed mainly in the retina. Mouse studies suggested that this gene is involved in development of retinal progenitors during embryogenesis, and that its activity is restricted to mature photoreceptors after birth. Mutations in this gene cause autosomal recessive retinitis pigmentosa-28. Alternatively spliced transcript variants have been identified.[provided by RefSeq, Jan 2011]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | FAM161A |
| Official Name | FAM161 centrosomal protein A [Source:HGNC Symbol;Acc:HGNC:25808] |
| Ensembl ID | ENSG00000170264 |
| Bio databases IDs | |
| Aliases | FAM161 centrosomal protein A |
| Synonyms | 4930430E16Rik, FAM161 centrosomal protein A, family with sequence similarity 161, member A, RGD1304999, RP28 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FAM161A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Uncharacterized protein family UPF0564
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- non-motile cilium
- basal bodies
- centrosome
- Golgi Apparatus
- centriole
- cytosol
- connecting cilia
- nucleoplasm
- spindle pole
- spindle fibers
- neurites
- photoreceptor inner segments
- astral microtubules
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FAM161A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- visual perception
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- spindle microtubule
- centrosome
- mitotic spindle
- cilium basal body
- cilium
- photoreceptor inner segment
- astral microtubule
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- microtubule binding