Fam161a Gene Summary [Mouse]
Predicted to enable identical protein binding activity and microtubule binding activity. Acts upstream of or within cilium organization. Located in microtubule organizing center; photoreceptor connecting cilium; and photoreceptor inner segment. Is expressed in several structures, including aorta; brain; eye; reproductive system; and respiratory system. Used to study retinitis pigmentosa 28. Human ortholog(s) of this gene implicated in retinitis pigmentosa 28. Orthologous to human FAM161A (FAM161 centrosomal protein A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fam161a |
| Official Name | family with sequence similarity 161, member A [Source:MGI Symbol;Acc:MGI:1921123] |
| Ensembl ID | ENSMUSG00000049811 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 161, member A |
| Synonyms | 4930430E16Rik, FAM161 centrosomal protein A, family with sequence similarity 161, member A, RGD1304999, RP28 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fam161a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Uncharacterized protein family UPF0564
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- non-motile cilium
- basal bodies
- centrosome
- Golgi Apparatus
- centriole
- cytosol
- connecting cilia
- nucleoplasm
- spindle pole
- spindle fibers
- neurites
- photoreceptor inner segments
- astral microtubules
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fam161a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- visual perception
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- spindle microtubule
- centrosome
- mitotic spindle
- cilium basal body
- cilium
- photoreceptor inner segment
- astral microtubule
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- microtubule binding