Puf60 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome; mRNA splice site recognition; and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cell junction and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Orthologous to human PUF60 (poly(U) binding splicing factor 60). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Puf60 |
| Official Name | poly-U binding splicing factor 60 [Source:RGD Symbol;Acc:621674] |
| Ensembl ID | ENSRNOG00000009960 |
| Bio databases IDs | |
| Aliases | poly-U binding splicing factor 60 |
| Synonyms | 2410104I19Rik, 2810454F19Rik, FIR, Fuse-binding protein-interacting repressor, poly-U binding splicing factor 60, poly(U) binding splicing factor 60, RoBPI, SIAHBP1, VRJS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Puf60 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- splicing factor, CC1-like family
- protein binding
- identical protein binding
- poly-U binding splicing factor, half-pint family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- colorectal cancer
- non-Hodgkin disease
- hematologic cancer
- hematological neoplasia
- thrombocytopenia
- lymphomagenesis
- lymphoid cancer
- lymphatic neoplasia
- CHARGE syndrome
role in cell
- apoptosis
- migration
- expression in
- cell death
- proliferation
- number
- repression in
- alternative splicing in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cell junction
- ribosome
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Puf60 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of alternative nuclear mRNA splicing, via spliceosome
- alternative nuclear mRNA splicing, via spliceosome
- apoptotic process
- mRNA splice site selection
Cellular Component
Where in the cell the gene product is active
- cell junction
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding
- RNA binding
- cadherin binding