Actn4 Gene Summary [Rat]
Enables ubiquitin protein ligase binding activity. A structural constituent of postsynaptic actin cytoskeleton. Involved in regulation of apoptotic process and response to hypoxia. Located in neuron projection and stress fiber. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 1. Orthologous to human ACTN4 (actinin alpha 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Actn4 |
| Official Name | actinin alpha 4 [Source:RGD Symbol;Acc:61816] |
| Ensembl ID | ENSRNOG00000020433 |
| Bio databases IDs | |
| Aliases | actinin alpha 4 |
| Synonyms | ACTININ 4, actinin alpha 4, actinin, alpha 4, actinin α 4, Alpha actinin 4, FSGS, FSGS1, NON-MUSCLE alpha-ACTININ, NON-MUSCLE α-ACTININ, α-actinin-4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Actn4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- transcription regulator
- transcription co-activator
- retinoic acid receptor binding
- chromatin binding
- Ca2+ insensitive EF hand
- EFh_PI-PLC
- EF-hand domain
- structural constituent of cytoskeleton
- actin binding
- ion channel binding
- SPEC
- ubiquitin protein ligase binding
- activation domain
- ligand-dependent nuclear receptor interactor
- Calponin homology domain
- nucleic acid binding
- EF-hand domain pair
- EFh
- protein binding
- sequence-specific DNA binding
- DNA binding
- EF hand like domain
- actin filament binding
- Spectrin repeats
- actin-binding domain
- binding protein
- double-stranded DNA binding
- integrin binding
- calponin homology (CH) domain superfamily
- protein homodimerization
- Spectrin repeat
- structural molecule
Pathways
Biological processes and signaling networks where the Actn4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- ILK Signaling
- Integrin Signaling
- Leukocyte Extravasation Signaling
- Macropinocytosis Signaling
- Paxillin Signaling
- Regulation of Cellular Mechanics by Calpain Protease
- Remodeling of Epithelial Adherens Junctions
- Sertoli Cell-Sertoli Cell Junction Signaling
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- neoplasia
- metastasis
- digestive system cancer
- cancer
- abdominal cancer
- breast cancer
- cervical squamous cell carcinoma
- advanced cancer
- liver cancer
role in cell
- binding
- migration
- expression in
- apoptosis
- morphology
- activation in
- formation
- formation in
- accumulation in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cytoplasmic face of endosomal membrane
- cortical cytoskeleton
- ruffle
- cortical actin cytoskeleton
- cytoskeleton
- cilia
- cell surface
- Extracellular Space
- cell periphery
- perinuclear region
- membrane surface
- focal adhesions
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- intercellular junctions
- cell-cell contacts
- cytosol
- membrane ruffles
- lateral plasma membrane
- alpha granules
- neurites
- Z line
- early endosomes
- actin stress fibers
- tight junctions
- membrane rafts
- cellular protrusions
- pseudopodia
- filopodia
- cell membrane leading edge
- exosomes
- lamellipodia
- microspikes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Actn4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle transport along actin filament
- protein transport
- muscle cell development
- negative regulation of substrate adhesion-dependent cell spreading
- regulation of apoptotic process
- positive regulation of transcription from RNA polymerase II promoter
- tumor necrosis factor-mediated signaling pathway
- retinoic acid receptor signaling pathway
- positive regulation of sodium:hydrogen antiporter activity
- actin cytoskeleton organization
- peroxisome proliferator activated receptor signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular region
- cell projection
- plasma membrane
- nucleus
- Z disc
- extracellular space
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- stress fiber
- actin cytoskeleton
- cell junction
- pseudopodium
- macromolecular complex
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- ligand-dependent nuclear receptor binding
- protein homodimerization activity
- RNA polymerase II regulatory region sequence-specific DNA binding
- integrin binding
- ion channel binding
- retinoic acid receptor binding
- nucleoside binding
- actin filament binding
- RNA binding
- protein binding
- actin binding
- transcription coactivator activity
- calcium ion binding
- ligand-dependent nuclear receptor transcription coactivator activity