Rabggtb Gene Summary [Rat]
Enables several functions, including Rab geranylgeranyltransferase activity; small GTPase binding activity; and zinc ion binding activity. Involved in protein geranylgeranylation. Part of Rab-protein geranylgeranyltransferase complex. Orthologous to human RABGGTB (Rab geranylgeranyltransferase subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rabggtb |
| Official Name | Rab geranylgeranyltransferase subunit beta [Source:RGD Symbol;Acc:3530] |
| Ensembl ID | ENSRNOG00000009992 |
| Bio databases IDs | |
| Aliases | Rab geranylgeranyltransferase subunit beta |
| Synonyms | Ggt2 β, GGTase II β, GGTB, Rab geranylgeranyl transferase, b subunit, Rab geranylgeranyltransferase subunit beta, Rab geranylgeranyltransferase subunit β, RABGGT beta, RABGGT β, β RabGGTase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rabggtb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prenyltransferase and squalene oxidase repeat
- ISOPREN_C2_like
- zinc ion binding
- enzyme binding
- enzyme
- protein binding
- isoprenoid binding
- RAB-protein geranylgeranyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- melanoma
- melanoma cancer
- systemic lupus erythematosus
- adenocarcinoma
- tumor
- large cell lung carcinoma
- large cell lung cancer
regulates
role in cell
- growth
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rabggtb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- protein geranylgeranylation
- visual perception
Cellular Component
Where in the cell the gene product is active
- Rab-protein geranylgeranyltransferase complex
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- small GTPase binding
- Rab geranylgeranyltransferase activity