Pxn Gene Summary [Rat]
Enables integrin binding activity and protein kinase binding activity. Involved in response to peptide. Located in focal adhesion. Orthologous to human PXN (paxillin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pxn |
| Official Name | paxillin [Source:RGD Symbol;Acc:1305759] |
| Ensembl ID | ENSRNOG00000001149 |
| Bio databases IDs | |
| Aliases | paxillin |
| Synonyms | FLJ23042, LOC108352464, PAX, PAXILLIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pxn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- leucine rich domain
- ERK-binding site
- integrin alpha 4 binding domain
- LD4 domain
- protein kinase binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- beta-catenin binding
- protein phosphatase binding
- protein domain specific binding
- protein binding
- receptor binding
- vinculin binding
- phosphorylation site
- MAP-kinase scaffold protein
- LIM binding domain
- binding protein
- Paxillin family
- receptor signaling complex scaffold protein
- integrin binding
- Src phosphorylation site
- paxillin LD motif
Pathways
Biological processes and signaling networks where the Pxn gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agrin Interactions at Neuromuscular Junction
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- G-Protein Coupled Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- Gα12/13 Signaling
- HGF Signaling
- IGF-1 Signaling
- Leukocyte Extravasation Signaling
- Natural Killer Cell Signaling
- PAK Signaling
- Paxillin Signaling
- Protein Kinase A Signaling
- Regulation of Cellular Mechanics by Calpain Protease
- Role of Tissue Factor in Cancer
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Dupuytren contracture
- organismal death
- metastasis
- rheumatoid arthritis
- non-small cell lung cancer
- dystrophy
role in cell
- proliferation
- phagocytosis by
- expression in
- apoptosis
- phosphorylation in
- invasion
- haptotaxis
- tyrosine phosphorylation in
- activation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- nuclear matrix fraction
- insoluble fractions
- cytoskeleton
- invadopodia
- cell-matrix contacts
- cell periphery
- perinuclear region
- cellular membrane
- focal complexes
- focal adhesions
- podosomes
- Plasma Membrane
- Endoplasmic Reticulum
- microtubules
- intercellular junctions
- immunological synapses
- cell-cell contacts
- microtubule organizing centers
- cytosol
- basolateral cell surfaces
- membrane ruffles
- basal membrane
- cell membrane-lagging edges
- growth cone
- neurites
- actin stress fibers
- cellular protrusions
- filopodia
- cell membrane leading edge
- perikaryon
- cell-matrix adherens junctions
- lamellipodia
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pxn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- growth hormone receptor signaling pathway
- signal complex assembly
- positive regulation of stress fiber assembly
- signal transduction
- substrate adhesion-dependent cell spreading
- transforming growth factor beta receptor signaling pathway
- cell adhesion
- endothelial cell migration
- cell migration
- cellular response to reactive oxygen species
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- focal adhesion
- cell cortex
- stress fiber
- cytosol
- plasma membrane
- microtubule associated complex
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein phosphatase binding
- metal ion binding
- vinculin binding
- beta-catenin binding