Pofut1 Gene Summary [Rat]
Predicted to enable peptide-O-fucosyltransferase activity. Predicted to be involved in protein O-linked fucosylation and regulation of Notch signaling pathway. Predicted to act upstream of or within several processes, including Notch signaling pathway; circulatory system development; and somitogenesis. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Dowling-Degos disease. Orthologous to human POFUT1 (protein O-fucosyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pofut1 |
| Official Name | protein O-fucosyltransferase 1 [Source:RGD Symbol;Acc:1303001] |
| Ensembl ID | ENSRNOG00000010104 |
| Bio databases IDs | |
| Aliases | protein O-fucosyltransferase 1 |
| Synonyms | DDD2, FUT12, O-Fuc-T, O-FucT-1, O-FUT, protein O-fucosyltransferase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pofut1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide-O-fucosyltransferase
- GDP-fucose protein O-fucosyltransferase and related proteins
- GDP-fucose protein O-fucosyltransferase
- lumenal domain
- fucosyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- growth failure
- organismal death
- Dowling-Degos disease type 2
- myeloid hyperplasia
- failure of heart looping
- gastric cancer
- hypoplasia
regulated by
- N-[N-(3,5-difluorophenacetyl-L-Ala)]-S-phenylglycine t-butyl ester
- GALC
- benzalkonium chloride
role in cell
- proliferation
- morphology
- expression in
- binding in
- migration
- production
- cisplatin resistance
- lymphopoiesis
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pofut1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- Notch signaling pathway
- protein O-linked glycosylation
- angiogenesis
- somitogenesis
- regulation of Notch signaling pathway
- protein O-linked fucosylation
- nervous system development
- regulation of transcription, DNA-dependent
- O-glycan processing
- fucose metabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- fucosyltransferase activity
- peptide-O-fucosyltransferase activity