F7 Gene Summary [Rat]
Enables endopeptidase activity and signaling receptor binding activity. Involved in several processes, including response to growth hormone; response to thyrotropin-releasing hormone; and response to thyroxine. Located in extracellular space and vesicle. Used to study asthma; diabetes mellitus; and type 2 diabetes mellitus. Biomarker of several diseases, including bilirubin metabolic disorder; familial hyperlipidemia; hypertension; hypothyroidism; and prothrombin deficiency. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebral infarction; diabetes mellitus (multiple); factor VII deficiency; and obesity. Orthologous to human F7 (coagulation factor VII). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | F7 |
| Official Name | coagulation factor VII [Source:RGD Symbol;Acc:628678] |
| Ensembl ID | ENSRNOG00000032737 |
| Bio databases IDs | |
| Aliases | coagulation factor VII |
| Synonyms | Cf7, coagulation factor VII, coagulation factor VIIa (recombinant), FVII, SPCA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat F7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- Tryp_SPc
- catalytic domain
- peptidase
- Human growth factor-like EGF
- serine protease domain
- Domain of unknown function (DUF1986)
- PACE cleavage site
- protein binding
- receptor binding
- EGF-like domain
- EGF_CA
- endopeptidase
- trypsin
- serine endopeptidase
- coagulation factor VIIa
- serine-type peptidase
- active site
- loop domain
- Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
- Coagulation Factor Xa inhibitory site
- EGF repeat
- hydrophobic domain
- calcium binding domain
Pathways
Biological processes and signaling networks where the F7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- non-insulin-dependent diabetes mellitus
- vascular leak syndrome
- androgenic alopecia
- bleeding
- factor VII deficiency
- myocardial infarction
- bleeding disorder
- dengue hemorrhagic fever
- hepatoblastoma
role in cell
- killing
- proliferation
- apoptosis
- formation
- formation in
- expression in
- activation in
- phosphorylation in
- migration
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi lumen
- cell surface
- Extracellular Space
- perinuclear region
- vesicles
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat F7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- positive regulation of blood coagulation
- response to vitamin K
- response to genistein
- positive regulation of positive chemotaxis
- response to growth hormone stimulus
- positive regulation of leukocyte chemotaxis
- blood coagulation
- circadian rhythm
- response to hypoxia
- response to thyroxine stimulus
- response to estradiol stimulus
- protein processing
- organ regeneration
- positive regulation of TOR signaling cascade
- response to carbon dioxide
- positive regulation of platelet-derived growth factor receptor signaling pathway
- positive regulation of cell migration
- response to cholesterol
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- vesicle
- Golgi lumen
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- serine-type peptidase activity
- serine-type endopeptidase activity
- receptor binding