Ttll1 Gene Summary [Rat]
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within several processes, including cerebellar Purkinje cell differentiation; mucociliary clearance; and protein polyglutamylation. Predicted to be located in cytoplasm; extracellular region; and motile cilium. Predicted to be active in ciliary basal body and microtubule. Orthologous to human TTLL1 (TTL family tubulin polyglutamylase complex subunit L1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ttll1 |
| Official Name | tubulin tyrosine ligase like 1 [Source:RGD Symbol;Acc:1309124] |
| Ensembl ID | ENSRNOG00000010141 |
| Bio databases IDs | |
| Aliases | tubulin tyrosine ligase like 1 |
| Synonyms | 6330444E16Rik, C22orf7, HS323M22B, PGs3, TPGS3, TTL family tubulin polyglutamylase complex subunit L1, tubulin tyrosine ligase-like 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ttll1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acid-D-amino acid ligase
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- colorectal cancer
- schizophrenia
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- seizures
- sneeze
- cough
- rhinosinusitis
regulates
- alpha tubulin
- beta tubulin
role in cell
- cell death
- assembly
- movement
- organization
- motility
- abnormal morphology
- beat
- curvature
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- basal bodies
- microtubules
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ttll1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyglutamylation
- cerebellar Purkinje cell differentiation
- sperm axoneme assembly
- immune response in nasopharyngeal-associated lymphoid tissue
- microtubule cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- motile cilium
- cytoplasm
- cilium basal body
- cilium
- extracellular region
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATP binding
- tubulin binding
- metal ion binding
- tubulin-glutamic acid ligase activity