Cdk5 Gene Summary [Rat]
Enables several functions, including ephrin receptor binding activity; protein kinase activity; and protein kinase binding activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of apoptotic process; and protein phosphorylation. Acts upstream of or within protein phosphorylation. Located in several cellular components, including growth cone; neuronal cell body; and postsynaptic density. Part of protein kinase 5 complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and neuromuscular junction. Used to study brain ischemia; depressive disorder; and trigeminal neuralgia. Biomarker of Alzheimer's disease; transient cerebral ischemia; and vascular dementia. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdk5 |
| Official Name | cyclin-dependent kinase 5 [Source:RGD Symbol;Acc:70514] |
| Ensembl ID | ENSRNOG00000008017 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase 5 |
| Synonyms | Crk6, cyclin-dependent kinase 5, LIS7, Neuronal cdc2-like kinase, PSSALRE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdk5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin-dependent protein kinase
- protein serine/threonine kinase
- acetylcholine receptor agonist
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- heat shock protein binding
- ephrin receptor binding
- enzyme
- p53 binding
- protein binding
- receptor binding
- Protein kinase domain
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- cytoskeletal protein binding
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- Neu/ErbB-2 receptor binding
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Cdk5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Amyloid Processing
- Axonal Guidance Signaling
- CDK5 Signaling
- Cell Cycle Control of Chromosomal Replication
- DNA Methylation and Transcriptional Repression Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- Neuregulin Signaling
- Reelin Signaling in Neurons
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tauopathy
- Huntington disease
- neurodegeneration
- Alzheimer disease
- neoplasia
- cancer
- COVID-19
- seizures
- cognitive impairment
- metastasis
role in cell
- dephosphorylation in
- expression in
- proliferation
- accumulation in
- activation
- differentiation
- phosphorylation in
- density
- binding
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule fractions
- synaptic plasma membrane fractions
- nuclear fraction
- soluble fraction
- detergent-insoluble fractions
- membrane fraction
- cytoplasmic cytoskeleton
- glutaminergic synapse
- cell junction
- Cytoplasm
- presynaptic regions
- cell periphery
- perinuclear region
- postsynaptic region
- cellular membrane
- focal adhesions
- actin cytoskeleton
- Plasma Membrane
- microtubules
- intermediate filaments
- cytosol
- membrane ruffles
- nucleoplasm
- sperm tail
- outer dense fibers
- dendritic spines
- neuromuscular junctions
- growth cone
- neurites
- synapse
- filopodia
- perikaryon
- axons
- dendrites
- postsynaptic density
- dendritic shafts
- lamellipodia
- microspikes
- detergent-soluble fraction
- vesicle fraction
- cytoskeletal fraction
- synaptosomal fractions
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdk5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- visual learning
- central nervous system neuron development
- intracellular protein transport
- receptor catabolic process
- negative regulation of transcription, DNA-dependent
- synaptic vesicle transport
- synaptic vesicle endocytosis
- negative regulation of synaptic plasticity
- axonogenesis
- regulation of synaptic plasticity
- regulation of cell cycle
- negative regulation of protein ubiquitination
- regulation of synaptic transmission, glutamatergic
- neuron apoptotic process
- regulation of dendritic spine morphogenesis
- regulation of excitatory postsynaptic membrane potential
- negative regulation of protein export from nucleus
- neuron differentiation
- synaptic transmission
- regulation of apoptotic process
- receptor clustering
- microtubule cytoskeleton organization
- corpus callosum development
- synapse assembly
- regulation of macroautophagy
- sensory perception of pain
- regulation of cell migration
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- calcium ion import
- layer formation in cerebral cortex
- positive regulation of protein targeting to membrane
- motor axon guidance
- Schwann cell development
- negative regulation of cell cycle
- negative regulation of proteolysis
- protein phosphorylation
- positive regulation of neuron apoptotic process
- cerebellar cortex formation
- dendrite morphogenesis
- cell division
- neuron migration
- synaptic transmission, dopaminergic
- behavioral response to cocaine
- phosphorylation
- protein localization to synapse
- synaptic vesicle exocytosis
- cell-matrix adhesion
- oligodendrocyte differentiation
- neuron projection development
- hippocampus development
- positive regulation of calcium ion-dependent exocytosis
- rhythmic process
- axon extension
- negative regulation of axon extension
- skeletal muscle tissue development
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cyclin-dependent protein kinase holoenzyme complex
- neuronal cell body
- perikaryon
- neuron projection
- plasma membrane
- nucleoplasm
- microtubule
- growth cone
- nucleus
- dendrite
- cytoplasm
- membrane
- cytosol
- cell junction
- filopodium
- neuromuscular junction
- cyclin-dependent protein kinase 5 holoenzyme complex
- axon
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- ErbB-2 class receptor binding
- protein kinase activity
- ErbB-3 class receptor binding
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity
- microtubule binding
- tau-protein kinase activity
- ATP binding
- acetylcholine receptor activator activity
- p53 binding
- protein binding
- tau protein binding
- Hsp90 protein binding
- kinase activity