Cd163 Gene Summary [Rat]
Predicted to enable scaffold protein binding activity. Located in cell surface. Biomarker of traumatic brain injury and uveitis. Orthologous to human CD163 (CD163 molecule). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd163 |
| Official Name | CD163 molecule [Source:RGD Symbol;Acc:1310382] |
| Ensembl ID | ENSRNOG00000010253 |
| Bio databases IDs | |
| Aliases | CD163 molecule |
| Synonyms | CD163 molecule, Ed2, HBSR, M130, MM130, SCARI1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd163 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- scavenger receptor
- SRCR domain
- protein binding
- cytosolic tail domain
- Scavenger receptor Cys-rich
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Cd163 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic retinopathy
- obesity
- epithelial cancer
- non-small cell lung cancer
- hepatocellular carcinoma
- liver cancer
- androgenic alopecia
- acute liver failure
- endometriosis
- atherosclerosis
role in cell
- production in
- proliferation
- expression in
- activation
- growth
- endocytosis by
- phagocytosis
- uptake
- detoxification in
- expansion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- endocytic vesicle membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- endosomes
- cytosol
- plasma membrane extracellular face
- trans Golgi network
- cis Golgi networks
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd163 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- acute-phase response
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- cytosol
- extracellular region
- endocytic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- protein binding
- scavenger receptor activity