Hp Gene Summary [Rat]
Enables hemoglobin binding activity and identical protein binding activity. Involved in several processes, including response to L-ascorbic acid; response to cobalamin; and response to growth hormone. Located in blood microparticle. Used to study obesity and type 1 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); kidney failure (multiple); liver disease (multiple); and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in Plasmodium falciparum malaria; artery disease (multiple); gout; hemolytic anemia; and hyperglycemia. Orthologous to several human genes including HP (haptoglobin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hp |
| Official Name | haptoglobin [Source:RGD Symbol;Acc:2825] |
| Ensembl ID | ENSRNOG00000014964 |
| Bio databases IDs | |
| Aliases | haptoglobin |
| Synonyms | Ba1-647, BP, haptoglobin, HAPTOGLOBIN-1 alpha-2 CHAIN, HAPTOGLOBIN 1 precursor, HAPTOGLOBIN-1 α-2 CHAIN, HAPTOGLOBIN-2 alpha-2 CHAIN, HAPTOGLOBIN-2 α-2 CHAIN, HAPTOGLOBIN alpha 2FS-beta, HAPTOGLOBIN α 2FS-β, HP-1, hp2-alpha, HP2ALPHA2, hp2-α, HPA1S, preHP2, PreR-Co, Zon1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- peptidase
- protein binding
- loop domain
- hemoglobin binding
- identical protein binding
- SUSHI repeat
Pathways
Biological processes and signaling networks where the Hp gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- adenoma formation
- epithelial cancer
- hepatocellular carcinoma
- acute myeloid leukemia
- breast cancer
- rheumatoid arthritis
- anhaptoglobinemia
- sepsis
- liver cancer
role in cell
- activation in
- expression in
- migration
- endocytosis by
- chemotaxis
- number
- uptake by
- transactivation in
- osteoclastogenesis
- injury
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- blood microparticle
- secretory granule lumen
- organelle lumens
- Nucleus
- endosomes
- cytosol
- cellular protrusions
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of oxidoreductase activity
- negative regulation of hydrogen peroxide catabolic process
- response to hydrogen peroxide
- defense response
- defense response to bacterium
- acute-phase response
- immune system process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- specific granule lumen
- endocytic vesicle lumen
- blood microparticle
- haptoglobin-hemoglobin complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- antioxidant activity
- hemoglobin binding
- serine-type endopeptidase activity