Ada Gene Summary [Rat]
Enables adenosine deaminase activity and purine nucleoside binding activity. Involved in several processes, including adenosine catabolic process; negative regulation of circadian sleep/wake cycle, non-REM sleep; and response to L-arginine. Located in dendrite cytoplasm; extracellular space; and neuronal cell body. Used to study hypertension; peritonitis; and pulmonary edema. Biomarker of several diseases, including glucose metabolism disease (multiple); leptospirosis; peritonitis; sporotrichosis; and trypanosomiasis. Human ortholog(s) of this gene implicated in asthma; colon cancer; pleural tuberculosis; severe combined immunodeficiency (multiple); and uterine fibroid. Orthologous to human ADA (adenosine deaminase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ada |
| Official Name | adenosine deaminase [Source:RGD Symbol;Acc:2031] |
| Ensembl ID | ENSRNOG00000010265 |
| Bio databases IDs | |
| Aliases | adenosine deaminase |
| Synonyms | ADA1, ADENOSINE DEAMINASE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ada often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- zinc ion binding
- adenosine deaminase
- alpha helix
- deoxyadenosine deaminase
- deaminase
- active site
- enzyme
- protein binding
- metallo-dependent_hydrolases
Pathways
Biological processes and signaling networks where the Ada gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- adenosine deaminase deficiency
- acute myeloid leukemia
- NK cell-negative B cell-negative T cell-negative autosomal recessive severe combined immunodeficiency due to adenosine deaminase deficiency
- severe combined immunodeficiency
- keratitis
- hairy cell leukemia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- brain ischemia
role in cell
- cellular infiltration by
- response
- expression in
- number
- degradation in
- growth
- migration
- phosphorylation in
- proliferation
- necrosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- Plasma Membrane
- lysosome
- cytosol
- plasma membrane extracellular face
- perikaryon
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ada gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of heart rate
- purine-containing compound salvage
- dAMP catabolic process
- hypoxanthine salvage
- negative regulation of penile erection
- negative regulation of adenosine receptor signaling pathway
- allantoin metabolic process
- lung alveolus development
- germinal center B cell differentiation
- response to hypoxia
- embryonic digestive tract development
- positive regulation of germinal center formation
- negative regulation of thymocyte apoptotic process
- thymocyte apoptotic process
- calcium-mediated signaling
- trophectodermal cell differentiation
- dATP catabolic process
- AMP salvage
- negative regulation of inflammatory response
- response to purine-containing compound
- B cell proliferation
- inosine biosynthetic process
- negative regulation of leukocyte migration
- penile erection
- xanthine biosynthetic process
- xenobiotic metabolic process
- positive regulation of B cell proliferation
- cellular amide catabolic process
- positive regulation of T cell differentiation in thymus
- T cell activation
- cell adhesion
- alpha-beta T cell differentiation
- placenta development
- positive regulation of alpha-beta T cell differentiation
- positive regulation of smooth muscle contraction
- positive regulation of calcium-mediated signaling
- adenosine metabolic process
- smooth muscle contraction
- liver development
- Peyer's patch development
- regulation of cell-cell adhesion mediated by integrin
- T cell receptor signaling pathway
- GMP salvage
- AMP catabolic process
- T cell differentiation in thymus
- purine nucleotide salvage
- deoxyadenosine catabolic process
- adenosine catabolic process
- positive regulation of T cell receptor signaling pathway
- germinal center formation
- mucus secretion
- mature B cell apoptotic process
- leukocyte migration
- negative regulation of mucus secretion
- negative regulation of mature B cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- anchoring junction
- membrane
- external side of plasma membrane
- cytosol
- plasma membrane
- cell surface
- lysosome
- cytoplasmic membrane-bounded vesicle lumen
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- deoxyadenosine deaminase activity
- protein binding
- adenosine deaminase activity
- deaminase activity