Chd3 Gene Summary [Rat]
Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; and histone binding activity. Predicted to be involved in chromatin remodeling; microtubule cytoskeleton organization; and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin organization. Predicted to be located in centriolar satellite; cytoplasm; and nuclear lumen. Predicted to be part of NuRD complex. Predicted to be active in chromatin and nucleus. Biomarker of pancreatic carcinoma. Orthologous to human CHD3 (chromodomain helicase DNA binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chd3 |
| Official Name | chromodomain helicase DNA binding protein 3 [Source:RGD Symbol;Acc:1311923] |
| Ensembl ID | ENSRNOG00000009722 |
| Bio databases IDs | |
| Aliases | chromodomain helicase DNA binding protein 3 |
| Synonyms | 2600010P09Rik, Chd7, chromodomain helicase DNA binding protein 3, HZFH, Mi-2a, Mi2-ALPHA, Mi2-α, MI alpha2, Prp7, Prp9-1, SNIBCPS, ZFH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- PHD zinc finger
- enzyme
- ATPase
- Helicase conserved C-terminal domain
- helicase domain
- zinc ion binding
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
- nucleic acid binding
- helicase superfamily c-terminal domain
- SNF2-related domain
- CHD subfamily II, SANT-like domain
- CR3 domain
- protein binding
- DNA dependent ATPase
- sequence-specific DNA binding
- CHDNT (NUC034) domain
- DNA binding
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- double-stranded DNA binding
- PHD finger superfamily
- Class II histone deacetylase complex subunits 2 and 3
- Chromo (CHRromatin organization MOdifier) domain
- CHDCT2 (NUC038) domain
Pathways
Biological processes and signaling networks where the Chd3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Snijders Blok-Campeau syndrome
- mental retardation
- ischemic stroke
- hereditary disorder
- prostate cancer
- epithelial cancer
- cancer
- prostatic carcinoma
- papillary renal cell carcinoma
- papillary renal cell neoplasia
role in cell
- organization
- cycling
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- nucleoplasm
- nucleoli
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- spindle organization
- chromatin remodeling
- regulation of cell fate specification
- negative regulation of transcription, DNA-dependent
- centrosome cycle
- positive regulation of transcription, DNA-dependent
- regulation of stem cell differentiation
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- PML body
- cytoplasm
- centriolar satellite
- NuRD complex
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- zinc ion binding
- RNA binding
- protein binding
- histone binding
- transcription regulatory region sequence-specific DNA binding
- helicase activity
- chromatin binding