Ninj2 Gene Summary [Rat]
The protein encoded by this gene belongs to the ninjurin (for nerve injury induced) family. It is a cell surface adhesion protein that is upregulated in Schwann cells surrounding the distal segment of injured nerve, and promotes neurite outgrowth, thus may have a role in nerve regeneration after nerve injury. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | Ninj2 |
| Official Name | ninjurin 2 [Source:RGD Symbol;Acc:620552] |
| Ensembl ID | ENSRNOG00000010282 |
| Bio databases IDs | |
| Aliases | ninjurin 2 |
| Synonyms | ninjurin 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ninj2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ninjurin
- cholesterol binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatic carditis
- organismal death
- glioblastoma
- glioblastoma cancer
- androgenic alopecia
- Hutchinson-Gilford progeria syndrome
regulates
role in cell
- growth
- expression in
- migration
- cell-cell adhesion
- outgrowth
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ninj2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- neuron cell-cell adhesion
- cell adhesion
- tissue regeneration
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding