Il3ra Gene Summary [Rat]
Predicted to enable cytokine binding activity and interleukin-3 receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and positive regulation of cell population proliferation. Predicted to act upstream of or within interleukin-3-mediated signaling pathway. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human IL3RA (interleukin 3 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il3ra |
| Official Name | interleukin 3 receptor subunit alpha [Source:RGD Symbol;Acc:628728] |
| Ensembl ID | ENSRNOG00000001325 |
| Bio databases IDs | |
| Aliases | interleukin 3 receptor subunit alpha |
| Synonyms | CD123, CYRL, hIL-3Ra, IL3R, IL-3R-alpha, IL3RAY, IL3RX, IL3RY, IL-3R-α, interleukin 3 receptor subunit alpha, interleukin 3 receptor subunit α, LOC686657 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il3ra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IL-3 receptor alpha chain N-terminal domain
- FN3
- intracellular domain
- interleukin-3 receptor
- protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il3ra gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- atopic dermatitis
- lymphomagenesis
- hematologic cancer
- graft-vs-host disease
- adult soft tissue sarcoma
- androgenic alopecia
- Crohn disease
- bladder cancer
- lymphoma
role in cell
- expression in
- colony formation by
- proliferation
- phosphorylation in
- differentiation
- activation in
- survival
- cell focus formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il3ra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- interleukin-3-mediated signaling pathway
- cytokine-mediated signaling pathway
- cellular response to interleukin-3
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-3 receptor activity
- cytokine binding
- cytokine receptor activity