Mrap2 Gene Summary [Rat]
Predicted to enable identical protein binding activity; melanocortin receptor binding activity; and signaling receptor regulator activity. Predicted to be involved in several processes, including negative regulation of protein localization to plasma membrane; protein localization to plasma membrane; and regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Orthologous to human MRAP2 (melanocortin 2 receptor accessory protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mrap2 |
| Official Name | melanocortin 2 receptor accessory protein 2 [Source:RGD Symbol;Acc:1309873] |
| Ensembl ID | ENSRNOG00000010545 |
| Bio databases IDs | |
| Aliases | melanocortin 2 receptor accessory protein 2 |
| Synonyms | bA51G5.2, C6orf117, melanocortin 2 receptor accessory protein 2, RGD1309873 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mrap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Melanocortin-2 receptor accessory protein family
- receptor regulator
- G-protein-coupled receptor binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atherosclerosis
- hepatic steatosis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- susceptibility to obesity type BMIQ18
- weight gain
- obesity
- hyperphagia
role in cell
- expression in
- production in
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mrap2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- energy homeostasis
- energy reserve metabolic process
- feeding behavior
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- corticotropin hormone receptor binding
- type 5 melanocortin receptor binding
- type 1 melanocortin receptor binding
- type 3 melanocortin receptor binding
- type 4 melanocortin receptor binding
- receptor regulator activity