Aplp2 Gene Summary [Rat]
Predicted to enable identical protein binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in axonogenesis and central nervous system development. Predicted to act upstream of or within several processes, including brain development; intracellular copper ion homeostasis; and suckling behavior. Predicted to be located in nucleus. Predicted to be active in spine apparatus. Used to study Alzheimer's disease. Biomarker of neurodegenerative disease. Orthologous to human APLP2 (amyloid beta precursor like protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aplp2 |
| Official Name | amyloid beta precursor like protein 2 [Source:RGD Symbol;Acc:2128] |
| Ensembl ID | ENSRNOG00000047179 |
| Bio databases IDs | |
| Aliases | amyloid beta precursor like protein 2 |
| Synonyms | ALID2, amyloid beta precursor-like protein 2, amyloid β precursor-like protein 2, APPH, APPL2, CDEBP, LOC100363366, LOC64312, WALPLP2, YWK-II |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aplp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
- JMTM_Notch_APP
- amyloid A4
- carbohydrate recognition domain
- ectodomain
- serine protease inhibitor activity
- Beta-amyloid precursor protein C-terminus
- E2 domain of amyloid precursor protein
- protein binding
- identical protein binding
- Amyloid A4 N-terminal heparin-binding
- Copper-binding of amyloid precursor, CuBD
- NPXY motif
- growth factor domain
- cytoplasmic domain
- copper binding domain
- transmembrane domain
- intracellular domain
- Kunitz-type domain
- Kunitz protease inhibitor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- ataxia
- dysplasia
- rheumatoid arthritis
- growth failure
- proliferative diabetic retinopathy
- motor neuron disease
- torticollis
role in cell
- expression in
- activation in
- migration
- molecular cleavage in
- quantity
- organization
- transactivation in
- adhesion
- long-term potentiation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic plasma membrane fractions
- membrane fraction
- organelle
- cell surface
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- Golgi Apparatus
- granules
- endoplasmic reticulum lumen
- perinuclear space
- alpha granules
- synaptic vesicles
- neurites
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aplp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- G-protein coupled receptor signaling pathway
- axonogenesis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- nucleus
- extracellular vesicular exosome
- platelet alpha granule membrane
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- transition metal ion binding
- identical protein binding
- serine-type endopeptidase inhibitor activity
- protein binding
- heparin binding