MRAP2 Gene Summary [Human]
This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | MRAP2 |
| Official Name | melanocortin 2 receptor accessory protein 2 [Source:HGNC Symbol;Acc:HGNC:21232] |
| Ensembl ID | ENSG00000135324 |
| Bio databases IDs | |
| Aliases | melanocortin 2 receptor accessory protein 2 |
| Synonyms | bA51G5.2, C6orf117, melanocortin 2 receptor accessory protein 2, RGD1309873 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MRAP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Melanocortin-2 receptor accessory protein family
- receptor regulator
- G-protein-coupled receptor binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atherosclerosis
- hepatic steatosis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- susceptibility to obesity type BMIQ18
- weight gain
- obesity
- hyperphagia
role in cell
- expression in
- production in
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MRAP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- energy homeostasis
- energy reserve metabolic process
- feeding behavior
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- corticotropin hormone receptor binding
- type 5 melanocortin receptor binding
- type 1 melanocortin receptor binding
- type 3 melanocortin receptor binding
- type 4 melanocortin receptor binding
- receptor regulator activity