Vps11 Gene Summary [Rat]
Predicted to enable several functions, including protein domain specific binding activity; syntaxin binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of intracellular estrogen receptor signaling pathway; positive regulation of early endosome to late endosome transport; and vesicle organization. Predicted to be located in actin filament; cytoplasmic vesicle; and lysosome. Predicted to be part of AP-3 adaptor complex; CORVET complex; and HOPS complex. Predicted to be active in endosome and presynaptic active zone. Human ortholog(s) of this gene implicated in dystonia 32 and hypomyelinating leukodystrophy 12. Orthologous to human VPS11 (VPS11 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps11 |
| Official Name | VPS11 core subunit of CORVET and HOPS complexes [Source:RGD Symbol;Acc:1308038] |
| Ensembl ID | ENSRNOG00000010733 |
| Bio databases IDs | |
| Aliases | VPS11 core subunit of CORVET and HOPS complexes |
| Synonyms | 1200011A11Rik, END1, HLD12, HLD12 DYT32, hVPS11, PEP5, RNF108, VPS11 core subunit of CORVET and HOPS complexes, VPS11, CORVET/HOPS core subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vps11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- Vacuolar protein sorting protein 11 C terminal
- protein domain specific binding
- Ring finger domain
- protein binding
- syntaxin binding
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- Region in Clathrin and VPS
- Clathrin heavy chain repeat homology
- RING-H2 zinc finger domain
- transporter
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Vps11 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hypomyelinating leukodystrophy type 12
- dystonia type 32
- coronary artery disease
- leukoencephalopathy
- androgenic alopecia
- infection by murine hepatitis virus
- infection by feline infectious peritonitis virus
regulates
role in cell
- assembly
- fusion
- pravastatin resistance
- recycling in
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- detergent resistant lipid raft fraction
- cellular membrane
- endosomes
- vesicles
- lysosome
- actin filaments
- cytosol
- endosomal membrane
- synapse
- early endosomes
- late endosomes
- endocytotic vesicle
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vps11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of SNARE complex assembly
- endosome organization
- vacuole organization
- positive regulation of protein catabolic process
- endosome to lysosome transport
- intracellular protein transport
- regulation of protein stability
- organelle fusion
- autophagy
- vesicle docking involved in exocytosis
- negative regulation of intracellular estrogen receptor signaling pathway
- positive regulation of early endosome to late endosome transport
- endosomal vesicle fusion
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- CORVET complex
- late endosome
- autophagic vacuole
- lysosomal membrane
- lysosome
- late endosome membrane
- endocytic vesicle
- early endosome
- endosome
- endosome membrane
- clathrin-coated vesicle
- HOPS complex
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- protein domain specific binding
- protein binding
- metal ion binding
- syntaxin binding
- protein binding, bridging