Vcl Gene Summary [Rat]
Enables small GTPase binding activity. Predicted to be involved in several processes, including cell-cell junction assembly; platelet aggregation; and protein localization to cell surface. Predicted to act upstream of or within axon extension; lamellipodium assembly; and regulation of cell migration. Located in several cellular components, including Z disc; actin cytoskeleton; and focal adhesion. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Orthologous to human VCL (vinculin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vcl |
| Official Name | vinculin [Source:RGD Symbol;Acc:1311217] |
| Ensembl ID | ENSRNOG00000010765 |
| Bio databases IDs | |
| Aliases | vinculin |
| Synonyms | 9430097D22, CMD1W, CMH15, HEL114, MV, MVCL, Vcl predicted, VINC, Vinculin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vcl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- alpha-catenin binding
- beta-catenin binding
- alpha helix
- paxillin-binding domain
- enzyme binding
- protein binding
- enzyme
- head domain
- proline rich domain
- arginine-lysine rich domain
- Vinculin family
- actin binding
- cadherin binding
- tail domain
- Hydrophobic hairpin domain
Pathways
Biological processes and signaling networks where the Vcl gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Epithelial Adherens Junction Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- ILK Signaling
- Integrin Signaling
- Leukocyte Extravasation Signaling
- Paxillin Signaling
- Regulation of Cellular Mechanics by Calpain Protease
- Remodeling of Epithelial Adherens Junctions
- Sertoli Cell-Sertoli Cell Junction Signaling
- Tight Junction Signaling
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- growth failure
- COVID-19
- primary dilated cardiomyopathy
- prostate cancer
- familial hypertrophic cardiomyopathy type 15
- essential thrombocythemia
- dilated cardiomyopathy
- hypertrophic cardiomyopathy
- atopic dermatitis
role in cell
- apoptosis
- morphology
- proliferation
- activation in
- expression in
- phosphorylation in
- migration
- invasion by
- growth
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- soluble fraction
- detergent-insoluble fractions
- detergent resistant lipid raft fraction
- filopodia-like projection
- secretory granule lumen
- ficolin-1-rich granule lumen
- cytoskeleton
- Cytoplasm
- cell-matrix contacts
- cell surface
- Extracellular Space
- cell periphery
- perinuclear region
- cellular membrane
- focal complexes
- focal adhesions
- podosomes
- actin cytoskeleton
- membrane skeleton
- Nucleus
- costameres
- actin filaments
- microtubule bundles
- intercellular junctions
- desmosomes
- cell-cell contacts
- cytoplasmic particles
- cytosol
- basal cell surfaces
- terminal web
- perinuclear space
- pedicels
- I band
- intercalated disks
- sarcolemma
- Z line
- transverse tubules
- actin stress fibers
- anchoring junction
- zonula adherens
- apical cell-cell contacts
- membrane rafts
- brush border
- cellular protrusions
- membrane processes
- cell membrane leading edge
- cell-cell adherens junctions
- cell-matrix adherens junctions
- plasma
- lamellipodia
- detergent-soluble fraction
- force transduction layer
- cytoskeletal fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vcl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- protein localization at cell surface
- epithelial cell-cell adhesion
- cell adhesion
- regulation of focal adhesion assembly
- axon extension
- morphogenesis of an epithelium
- apical junction assembly
- lamellipodium assembly
- adherens junction assembly
- platelet aggregation
- maintenance of blood-brain barrier
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- specific granule lumen
- costamere
- extracellular region
- cell projection
- plasma membrane
- cell-cell contact zone
- adherens junction
- cell-cell junction
- cytoskeleton
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- fascia adherens
- sarcolemma
- cell-substrate junction
- cytosol
- secretory granule lumen
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- alpha-catenin binding
- protein binding
- ubiquitin protein ligase binding
- actin binding
- cadherin binding
- structural molecule activity
- dystroglycan binding
- beta-catenin binding