Bmp5 Gene Summary [Rat]
Predicted to enable BMP receptor binding activity and cytokine activity. Predicted to be involved in several processes, including chordate embryonic development; heart development; and negative regulation of steroid hormone biosynthetic process. Predicted to act upstream of or within several processes, including anterior head development; ear development; and male genitalia development. Located in extracellular space and vesicle. Orthologous to human BMP5 (bone morphogenetic protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmp5 |
| Official Name | bone morphogenetic protein 5 [Source:RGD Symbol;Acc:1305979] |
| Ensembl ID | ENSRNOG00000010917 |
| Bio databases IDs | |
| Aliases | bone morphogenetic protein 5 |
| Synonyms | bone morphogenetic protein 5, se |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bmp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TGF_beta_SF
- Transforming growth factor beta like domain
- protein binding
- receptor binding
- growth factor
- TGF-beta propeptide
Pathways
Biological processes and signaling networks where the Bmp5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- BMP signaling pathway
- Cardiomyocyte Differentiation via BMP Receptors
- Factors Promoting Cardiogenesis in Vertebrates
- Human Embryonic Stem Cell Pluripotency
- Iron homeostasis signaling pathway
- Molecular Mechanisms of Cancer
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proteinuria
- prostate cancer
- colorectal cancer
- rheumatoid arthritis
- adrenal cortex carcinoma
- adrenocortical carcinoma
- inguinal hernia
- colorectal adenoma
- colorectal adenoma formation
- osteoarthritis
role in cell
- phosphorylation in
- expression in
- proliferation
- apoptosis
- production in
- differentiation
- invasion
- cell viability
- development
- steroidogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bmp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cortisol biosynthetic process
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- endocardial cushion formation
- positive regulation of transcription from RNA polymerase II promoter
- cardiac muscle tissue development
- negative regulation of insulin-like growth factor receptor signaling pathway
- skeletal system development
- negative regulation of epithelial to mesenchymal transition
- ossification
- hindbrain development
- BMP signaling pathway
- positive regulation of SMAD protein import into nucleus
- negative regulation of mononuclear cell migration
- negative regulation of aldosterone biosynthetic process
- positive regulation of epithelial cell proliferation
- negative regulation of steroid biosynthetic process
- heart trabecula morphogenesis
- pattern specification process
- neural fold elevation formation
- cardiac septum morphogenesis
- pharyngeal system development
- positive regulation of dendrite development
- pericardium morphogenesis
- anterior head development
- chorio-allantoic fusion
- type B pancreatic cell development
- male genitalia development
- ear development
- cartilage development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- vesicle
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- cytokine activity
- BMP receptor binding