Mfn1 Gene Summary [Rat]
Enables identical protein binding activity. Involved in several processes, including regulation of mitochondrion organization; response to glucocorticoid; and response to hypoxia. Located in mitochondrial inner membrane and mitochondrial outer membrane. Biomarker of several diseases, including adult respiratory distress syndrome; dental fluorosis; kidney failure (multiple); pulmonary hypertension; and status epilepticus. Orthologous to human MFN1 (mitofusin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mfn1 |
| Official Name | mitofusin 1 [Source:RGD Symbol;Acc:621460] |
| Ensembl ID | ENSRNOG00000011057 |
| Bio databases IDs | |
| Aliases | mitofusin 1 |
| Synonyms | 2310002F04RIK, 6330416C07Rik, D3Ertd265e, Fzo1b, hfzo1, hfzo2, HR2, mitofusin 1, mKIAA4032 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mfn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fzo-like conserved region
- GTPase
- enzyme
- protein binding
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- Dynamin family
Pathways
Biological processes and signaling networks where the Mfn1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- cancer
- neoplasia
- metastasis
- COVID-19
- breast carcinoma
- chronic lymphocytic leukemia
- weight gain
- idiopathic scoliosis
- advanced cancer
role in cell
- formation
- formation in
- expression in
- apoptosis
- migration
- quantity
- proliferation
- invasion by
- production in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cell surface
- cellular membrane
- Mitochondria
- mitochondrial matrix
- mitochondrial outer membrane
- mitochondrial inner membrane
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mfn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mitochondrial membrane potential
- mitochondrial fusion
- GTP metabolic process
- mitochondrion localization
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- membrane
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- protein binding
- GTPase activity