Cycs Gene Summary [Rat]
Enables enzyme binding activity. Involved in several processes, including mitochondrial electron transport, cytochrome c to oxygen; negative regulation of hydrogen peroxide biosynthetic process; and response to ischemia. Located in cytosol. Human ortholog(s) of this gene implicated in cholangiocarcinoma; lung non-small cell carcinoma; pancreatic cancer; and thrombocytopenia. Orthologous to human CYCS (cytochrome c, somatic). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cycs |
| Official Name | cytochrome c, somatic [Source:RGD Symbol;Acc:2451] |
| Ensembl ID | ENSRNOG00000010452 |
| Bio databases IDs | |
| Aliases | cytochrome c, somatic |
| Synonyms | CYC, CYCSA, CYTC, CYTOC, CYTOCHROME C, cytochrome c, somatic, HCS, THC4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cycs often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome C
- Cytochrome C oxidase, cbb3-type, subunit III
- enzyme binding
- Di-haem oxidoreductase, putative peroxidase
- enzyme
- protein binding
- heme binding
Pathways
Biological processes and signaling networks where the Cycs gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Apoptosis Signaling
- CD27 Signaling in Lymphocytes
- Ceramide Signaling
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Death Receptor Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Granzyme B Signaling
- Huntington's Disease Signaling
- Induction of Apoptosis by HIV1
- Lymphotoxin β Receptor Signaling
- Molecular Mechanisms of Cancer
- Myc Mediated Apoptosis Signaling
- Nur77 Signaling in T Lymphocytes
- Parkinson's Signaling
- Retinoic acid Mediated Apoptosis Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- Small Cell Lung Cancer Signaling
- TNFR1 Signaling
- Tumoricidal Function of Hepatic Natural Killer Cells
- TWEAK Signaling
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic autoimmune hepatitis
- systemic lupus erythematosus
- glycogen storage disease type II
- COVID-19
- psoriasis
- primary sclerosing cholangitis
- Huntington disease
- organismal death
- epithelial cancer
- viral hepatitis
role in cell
- expression in
- apoptosis
- cell death
- formation
- transmembrane potential
- homeostasis
- activity
- respiration
- fusion
- respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- membrane fraction
- mitochondrial fraction
- perinuclear region
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- apoptosome
- cytosol
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial intermembrane space
- mitochondrial inner membrane
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cycs gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- mitochondrial electron transport, cytochrome c to oxygen
- cellular respiration
- intrinsic apoptotic signaling pathway
- mitochondrial electron transport, ubiquinol to cytochrome c
- execution phase of apoptosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial intermembrane space
- apoptosome
- mitochondrion
- cytosol
- respiratory chain
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- electron carrier activity
- heme binding