Unc119 Gene Summary [Rat]
Predicted to enable lipid binding activity. Predicted to be involved in several processes, including lipoprotein transport; negative regulation of endocytosis; and positive regulation of protein tyrosine kinase activity. Predicted to be located in cytoplasm. Predicted to be active in intercellular bridge and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in cone-rod dystrophy 24 and immunodeficiency 13. Orthologous to human UNC119 (unc-119 lipid binding chaperone). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Unc119 |
| Official Name | unc-119 lipid binding chaperone [Source:RGD Symbol;Acc:3942] |
| Ensembl ID | ENSRNOG00000011060 |
| Bio databases IDs | |
| Aliases | unc-119 lipid binding chaperone |
| Synonyms | CORD24, D11Bhm52, HRG4, IMD13, MRG4, POC7, POC7A, Rg4, RRG4, Rtg4, UNC119A, UNC119H, unc-119 lipid binding chaperone, Uncl19 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Unc119 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GMP-PDE, delta subunit
- lipid binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cone-rod dystrophy type 24
- idiopathic CD4+ T-lymphocytopenia
- cone-rod dystrophy
role in cell
- apoptosis
- proliferation
- migration
- survival
- invasion by
- colony formation by
- interaction in
- synaptic transmission
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytoplasmic bridges
- cytosol
- spindle pole
- central spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Unc119 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of clathrin-mediated endocytosis
- positive regulation of protein tyrosine kinase activity
- cytokinesis after mitosis
- nervous system development
- synaptic transmission
- negative regulation of caveolin-mediated endocytosis
- endocytosis
- visual perception
- phototransduction
- lipoprotein transport
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- centrosome
- spindle midzone
- spindle pole
- cytosol
- synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- lipid binding