Tp53bp2 Gene Summary [Rat]
Predicted to enable NF-kappaB binding activity; p53 binding activity; and protein homodimerization activity. Predicted to be involved in intrinsic apoptotic signaling pathway by p53 class mediator and positive regulation of execution phase of apoptosis. Predicted to act upstream of or within several processes, including embryo development; heart development; and response to ionizing radiation. Predicted to be located in cell junction; cytosol; and perinuclear region of cytoplasm. Predicted to be active in nucleus. Orthologous to human TP53BP2 (tumor protein p53 binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tp53bp2 |
| Official Name | tumor protein p53 binding protein, 2 [Source:RGD Symbol;Acc:1305461] |
| Ensembl ID | ENSRNOG00000003237 |
| Bio databases IDs | |
| Aliases | tumor protein p53 binding protein, 2 |
| Synonyms | 53BP2, ASPP2, p53-Binding, P53BP2, PPP1R13A, transformation related protein 53 binding protein 2, Trp53bp2, tumor protein p53 binding protein 2, tumor protein p53 binding protein, 2, tumour protein p53 binding protein 2, tumour protein p53 binding protein, 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tp53bp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Coiled-coil region of CCDC155 or KASH
- Ankyrin repeats (many copies)
- NF-kappaB binding
- Ankyrin repeats (3 copies)
- p53 binding
- protein binding
- proline rich domain
- identical protein binding
- proline tyrosine motif
- Ankyrin repeat
- Src Homology 3 domain superfamily
- Ubl1_cv_Nsp3_N-like
- Growth-arrest specific micro-tubule binding
- protein homodimerization
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Tp53bp2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- neuroinflammation
- peripheral arterial disease
- metastasis
- multiple sclerosis
- encephalitis
- open-angle glaucoma
- systemic lupus erythematosus
role in cell
- growth
- proliferation
- expression in
- activation in
- cell death
- apoptosis
- phosphorylation in
- binding in
- transmembrane potential
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- Cytoplasm
- perinuclear region
- vesicles
- cytosol
- nucleoplasm
- perinuclear vesicles
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tp53bp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- signal transduction by p53 class mediator resulting in induction of apoptosis
- negative regulation of cell cycle
- positive regulation of execution phase of apoptosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- cell junction
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- p53 binding
- identical protein binding
- protein binding
- protein homodimerization activity
- SH3 domain binding