Smn1 Gene Summary [Rat]
Enables fibroblast growth factor binding activity. Involved in chemical synaptic transmission. Located in Gemini of Cajal bodies. Human ortholog(s) of this gene implicated in Werdnig-Hoffmann disease; adult spinal muscular atrophy; intermediate spinal muscular atrophy; juvenile spinal muscular atrophy; and spinal muscular atrophy. Orthologous to several human genes including SMN1 (survival of motor neuron 1, telomeric). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smn1 |
| Official Name | survival of motor neuron 1, telomeric [Source:RGD Symbol;Acc:620755] |
| Ensembl ID | ENSRNOG00000018067 |
| Bio databases IDs | |
| Aliases | survival of motor neuron 1, telomeric |
| Synonyms | Gemin1, Smn, survival motor neuron 1, survival of motor neuron 1, telomeric |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Smn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Survival motor neuron protein (SMN)
- fibroblast growth factor binding
- protein binding
- identical protein binding
- Tudor domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- synaptic dysfunction
- weight loss
- mitochondrial disorder
- motor dysfunction
- spinal muscular atrophy type II
- neurodegeneration
- tubulo-interstitial fibrosis
role in cell
- growth
- expression in
- apoptosis
- cell death
- formation
- size
- quantity
- number
- maturation
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- Golgi Apparatus
- cytosol
- gems
- nucleoplasm
- nucleoli
- nuclear bodies
- coiled body
- Cajal bodies
- growth cone
- neurites
- nerve ending
- perikaryon
- motor axons