Lzts1 Gene Summary [Rat]
Involved in regulation of dendrite morphogenesis and regulation of synaptic plasticity. Located in several cellular components, including apical plasma membrane; dendrite; and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in breast carcinoma; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human LZTS1 (leucine zipper tumor suppressor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lzts1 |
| Official Name | leucine zipper tumor suppressor 1 [Source:RGD Symbol;Acc:708565] |
| Ensembl ID | ENSRNOG00000011826 |
| Bio databases IDs | |
| Aliases | leucine zipper tumor suppressor 1 |
| Synonyms | F37, FEZ1, Gm7677, leucine zipper, putative tumor suppressor 1, leucine zipper, putative tumour suppressor 1, leucine zipper tumor suppressor 1, leucine zipper tumour suppressor 1, PSDZIP70 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lzts1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fez1
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- gastrointestinal neoplasia
- squamous cell cancer
- liver cancer
- liver neoplasia
regulates
- RAP2A
- RAP2
role in cell
- proliferation
- apoptosis
- quantity
- formation
- growth
- number
- colony formation
- tumorigenicity
- transmission
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- glutaminergic synapse
- Cytoplasm
- Plasma Membrane
- microtubules
- apical membrane
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- postsynaptic spines
- perikaryon
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lzts1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synaptic plasticity
- negative regulation of macroautophagy
- regulation of dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cytoplasm
- dendritic spine
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding