Calcb Gene Summary [Rat]
Predicted to enable calcitonin receptor binding activity and hormone activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; calcitonin gene-related peptide receptor signaling pathway; and regulation of cytosolic calcium ion concentration. Predicted to be active in extracellular space. Orthologous to human CALCB (calcitonin related polypeptide beta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Calcb |
| Official Name | calcitonin-related polypeptide, beta [Source:RGD Symbol;Acc:620997] |
| Ensembl ID | ENSRNOG00000011074 |
| Bio databases IDs | |
| Aliases | calcitonin-related polypeptide, beta |
| Synonyms | CALC2, calcitonin related polypeptide beta, calcitonin-related polypeptide, beta, calcitonin related polypeptide β, calcitonin-related polypeptide, β, CGRP2, CGRP-II |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Calcb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcitonin / CGRP / IAPP family
- calcitonin
- hormone
- protein binding
- neuropeptide hormone
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- sepsis
- migraines
- chronic cluster headache
- cluster headache
- COVID-19
- migraine without aura
- diverticulitis
- migraine with aura
- inflammatory disorder
role in cell
- expression in
- proliferation
- production in
- responsiveness
- activation in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Calcb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cytosolic calcium ion homeostasis
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcitonin receptor binding
- neuropeptide hormone activity