CALCB Gene Summary [Human]
Predicted to enable calcitonin receptor binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of cytosolic calcium ion concentration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CALCB |
| Official Name | calcitonin related polypeptide beta [Source:HGNC Symbol;Acc:HGNC:1438] |
| Ensembl ID | ENSG00000175868 |
| Bio databases IDs | |
| Aliases | calcitonin related polypeptide beta |
| Synonyms | CALC2, calcitonin related polypeptide beta, calcitonin-related polypeptide, beta, calcitonin related polypeptide β, calcitonin-related polypeptide, β, CGRP2, CGRP-II |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CALCB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcitonin / CGRP / IAPP family
- calcitonin
- hormone
- protein binding
- neuropeptide hormone
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- sepsis
- migraines
- chronic cluster headache
- cluster headache
- COVID-19
- migraine without aura
- diverticulitis
- migraine with aura
- inflammatory disorder
role in cell
- expression in
- proliferation
- production in
- responsiveness
- activation in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CALCB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cytosolic calcium ion homeostasis
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcitonin receptor binding
- neuropeptide hormone activity