Blm Gene Summary [Rat]
Predicted to enable several functions, including ATP binding activity; DNA binding activity; and DNA helicase activity. Predicted to be involved in several processes, including DNA geometric change; DNA metabolic process; and regulation of primary metabolic process. Predicted to act upstream of or within several processes, including T cell differentiation; positive regulation of T cell proliferation; and regulation of DNA recombination. Predicted to be located in chromosome; cytosol; and nucleus. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in chromosome; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in Bloom syndrome. Orthologous to human BLM (BLM RecQ like helicase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Blm |
| Official Name | BLM RecQ like helicase [Source:RGD Symbol;Acc:1308810] |
| Ensembl ID | ENSRNOG00000011213 |
| Bio databases IDs | |
| Aliases | BLM RecQ like helicase |
| Synonyms | BLM RecQ like helicase, Blooms syndrome, Bloom syndrome, Bloom syndrome, RecQ like helicase, BS, MGRISCE1, RECQ2, RECQL2, RECQL3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Blm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helicase and RNase D C-terminal
- ATP-dependent DNA helicase, RecQ family
- helicase
- DNA secondary structure binding
- ATP binding
- enzyme
- identical protein binding
- Helicase conserved C-terminal domain
- RQC domain
- holliday junction helicase
- telomeric DNA binding
- DNA helicase
- helicase domain
- BDHCT-box associated domain on Bloom syndrome protein
- zinc ion binding
- RecQ zinc-binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- BDHCT (NUC031) domain
- DEAD-like helicases superfamily
- p53-binding domain
- N-terminal region of Bloom syndrome protein
- P-loop containing Nucleoside Triphosphate Hydrolases
- HRDC domain
- nucleic acid binding
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- isomerase
- PRK11057
- protein binding
- p53 binding
- DNA dependent ATPase
- DNA binding
- phosphorylation site
- damaged DNA binding
- single-stranded DNA binding
- RQC
- protein homodimerization
- ATP-dependent DNA helicase RecQ
Pathways
Biological processes and signaling networks where the Blm gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- invasive breast cancer
- colon adenocarcinoma
- colorectal cancer
- hepatocellular carcinoma
- esophageal squamous cell carcinoma
- rectum cancer
- neoplasia
- ovarian cancer
- tumorigenesis
role in cell
- expression in
- apoptosis
- damage
- cell viability
- growth
- proliferation
- quantity
- upregulation in
- accumulation in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasmic fraction
- nuclear matrix fraction
- detergent-insoluble fractions
- Cytoplasm
- cytosol
- nuclear foci
- chromosome
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear speckles
- nuclear matrix
- pronucleus
- PML nuclear bodies
- synaptonemal complexes
- telomeres
- chromosomal axial elements
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Blm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- DNA repair
- response to X-ray
- DNA double-strand break processing
- DNA replication
- double-strand break repair via homologous recombination
- protein homooligomerization
- DNA recombination
- telomere maintenance
- response to DNA damage stimulus
- DNA unwinding involved in replication
- negative regulation of DNA recombination
- regulation of cyclin-dependent protein kinase activity
- positive regulation of transcription, DNA-dependent
- negative regulation of cell division
- DNA duplex unwinding
- cellular response to ionizing radiation
- telomere maintenance via semi-conservative replication
- resolution of recombination intermediates
- cellular response to hydroxyurea
- replication fork processing
- protein oligomerization
- regulation of DNA-dependent DNA replication
Cellular Component
Where in the cell the gene product is active
- PML body
- lateral element
- nuclear chromosome
- chromosome
- nucleolus
- nucleoplasm
- replication fork
- chromosome, telomeric region
- nucleus
- cytoplasm
- nuclear matrix
- cytosol
- macromolecular complex
- RecQ helicase-Topo III complex
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- identical protein binding
- DNA-dependent ATPase activity
- zinc ion binding
- protein homodimerization activity
- bubble DNA binding
- helicase activity
- Y-form DNA binding
- four-way junction helicase activity
- 3'-5' DNA helicase activity
- four-way junction DNA binding
- single-stranded DNA binding
- ATP binding
- DNA binding
- DNA helicase activity
- p53 binding
- protein binding
- G-quadruplex DNA binding
- isomerase activity