Xrcc2 Gene Summary [Rat]
Predicted to enable ATP binding activity and ATP-dependent DNA damage sensor activity. Predicted to contribute to four-way junction DNA binding activity. Predicted to be involved in DNA recombination; centrosome cycle; and mitotic cell cycle. Predicted to act upstream of or within several processes, including chordate embryonic development; regulation of apoptotic process; and response to X-ray. Predicted to be located in nucleoplasm. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Predicted to be active in centrosome and replication fork. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group U; pancreatic cancer; primary ovarian insufficiency 17; and spermatogenic failure 50. Orthologous to human XRCC2 (X-ray repair cross complementing 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Xrcc2 |
| Official Name | X-ray repair cross complementing 2 [Source:RGD Symbol;Acc:1564823] |
| Ensembl ID | ENSRNOG00000007493 |
| Bio databases IDs | |
| Aliases | X-ray repair cross complementing 2 |
| Synonyms | 4921524O04Rik, 8030409M04Rik, FANCU, LOC102553514, POF17, RAD51, RecA, RGD1564823, SPGF50, X-ray repair complementing defective repair in Chinese hamster cells 2, X-ray repair cross complementing 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Xrcc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- walker type A motif
- DNA secondary structure binding
- Rad51
- enzyme
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
Pathways
Biological processes and signaling networks where the Xrcc2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- lymphomagenesis
- non-Hodgkin disease
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
role in cell
- formation
- apoptosis
- cell death
- survival
- growth
- molecular cleavage in
- development
- early S phase
- exchange
- sister chromatid exchange
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- centrosome
- nuclear foci
- nucleoplasm
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Xrcc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- DNA repair
- response to X-ray
- centrosome cycle
- double-strand break repair via homologous recombination
- neurogenesis
- strand invasion
- mitotic cell cycle
- negative regulation of neuron apoptotic process
- meiotic cell cycle
- in utero embryonic development
- somitogenesis
- positive regulation of neurogenesis
- response to gamma radiation
- regulation of fibroblast apoptotic process
Cellular Component
Where in the cell the gene product is active
- replication fork
- Rad51B-Rad51C-Rad51D-XRCC2 complex
- centrosome
- cytoplasm
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- four-way junction DNA binding