AABR07031193.1 Gene Summary [Rat]
Predicted to be an extracellular matrix structural constituent. Involved in cell-cell adhesion and hemidesmosome assembly. Located in adherens junction and hemidesmosome. Part of laminin-3 complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and lung small cell carcinoma. Orthologous to human LAMA3 (laminin subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | AABR07031193.1 |
| Official Name | laminin subunit alpha 3 [Source:NCBI gene;Acc:307582] |
| Ensembl ID | ENSRNOG00000011300 |
| Bio databases IDs | |
| Aliases | laminin subunit alpha 3 |
| Synonyms | [a]3B, AABR07031193.1, BM600, E170, JEB2A, JEB2B, JEB2C, Lama3B, Laminin 5 α 3, laminin, alpha 3, laminin subunit alpha 3, laminin subunit α 3, Laminin α 3, laminin, α 3, Laminin α 3 subunit precursor, LAMNA, LOCS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aabr07031193.1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- Laminin N-terminal (Domain VI)
- LamG
- Laminin B (Domain IV)
- globular domain
- protein binding
- Laminin Domain II
- Tumor necrosis factor receptor superfamily (TNFRSF)
- Helical bimodular sensor domain
- EGF_CA
- Laminin Domain I
- laminin-G repeat
- Coiled-coil domain-containing protein 149-A
- Laminin-type epidermal growth factor-like domai
- Concanavalin A-like lectin/glucanases superfamily
- Mechanosensitive ion channel porin domain
- laminin-type G domain 5 module
- Septation ring formation regulator, EzrA
- laminin-type G domain 4 module
- laminin G domain
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the Aabr07031193.1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- epithelial ovarian cancer
- bleeding
- epidermolysis bullosa letalis
- breast carcinoma
- allergic rhinitis
- metastatic colorectal cancer
- laryngo-onychocutaneous syndrome
- junctional epidermolysis bullosa
- tinnitus
role in cell
- adhesion
- apoptosis
- survival
- quantity
- proliferation
- binding
- abnormal morphology
- morphology
- outgrowth
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- apical ectoplasmic specialization
- Endoplasmic Reticulum
- hemidesmosomes
- extracellular matrix
- basal lamina
- cell-cell adherens junctions
- interphotoreceptor matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aabr07031193.1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hemidesmosome assembly
- regulation of embryonic development
- epidermis development
- endodermal cell differentiation
- regulation of cell adhesion
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- adherens junction
- basement membrane
- extracellular vesicular exosome
- laminin-3 complex
- endoplasmic reticulum
- hemidesmosome
- extracellular region
- laminin-5 complex
Molecular Function
What the gene product does at the molecular level
- structural molecule activity
- extracellular matrix structural constituent
- receptor binding