Sdc1 Gene Summary [Rat]
Predicted to enable cargo receptor activity and identical protein binding activity. Involved in several processes, including Sertoli cell development; response to cAMP; and response to hydrogen peroxide. Part of protein-containing complex. Used to study familial hyperlipidemia. Biomarker of myocardial infarction; obesity; and proteinuria. Orthologous to human SDC1 (syndecan 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sdc1 |
| Official Name | syndecan 1 [Source:RGD Symbol;Acc:3648] |
| Ensembl ID | ENSRNOG00000059947 |
| Bio databases IDs | |
| Aliases | syndecan 1 |
| Synonyms | BB4, CD138, HSPG, SDC, Sdc1 variant 1v, Sstn, syn-1, Syn-1v, Synd, SYND1, SYNDECA, Syndecan, syndecan 1, Syndecan-1v, Z48199 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sdc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cargo receptor activity
- variable domain
- extracellular matrix binding
- ectodomain
- enzyme
- protein binding
- identical protein binding
- integrin binding domain
- putative band 4.1 homologues' binding motif
- Syndecan domain
- core
- cytoplasmic domain
- transmembrane domain
- C2 region of the Syndecan family
Pathways
Biological processes and signaling networks where the Sdc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Parkinson disease
- osteoarthritis
- hyperplasia
- breast cancer
- organismal death
- metastatic colorectal cancer
- metastasis
- Hutchinson-Gilford progeria syndrome
- idiopathic pulmonary fibrosis
role in cell
- activation in
- expression in
- apoptosis
- proliferation
- survival
- differentiation
- phosphorylation in
- migration
- quantity
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- detergent resistant lipid raft fraction
- Golgi lumen
- Cytoplasm
- cell surface
- Extracellular Space
- cell periphery
- cellular membrane
- cell-cell contacts
- plasma membrane extracellular face
- uropod
- basolateral membrane
- basal membrane
- sinusoidal membrane
- lateral plasma membrane
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sdc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cAMP
- Sertoli cell development
- response to hydrogen peroxide
- response to toxin
- receptor-mediated endocytosis
- myoblast development
- ureteric bud development
- response to calcium ion
- response to glucocorticoid stimulus
- striated muscle cell development
- canonical Wnt receptor signaling pathway
- cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- external side of plasma membrane
- lysosomal lumen
- macromolecular complex
- Golgi lumen
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cargo receptor activity