Lgi3 Gene Summary [Rat]
Predicted to be involved in regulation of exocytosis. Predicted to be located in extracellular space and juxtaparanode region of axon. Predicted to be active in synaptic vesicle. Orthologous to human LGI3 (leucine rich repeat LGI family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lgi3 |
| Official Name | leucine-rich repeat LGI family, member 3 [Source:RGD Symbol;Acc:1311079] |
| Ensembl ID | ENSRNOG00000011323 |
| Bio databases IDs | |
| Aliases | leucine-rich repeat LGI family, member 3 |
| Synonyms | AI841179, IDDMDS, leucine rich repeat LGI family member 3, leucine-rich repeat LGI family, member 3, LGIL4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lgi3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- leucine-rich repeat
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- protein binding
- Leucine Rich repeats (2 copies)
- EPTP domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- intellectual developmental disorder with muscle tone abnormalities and distal skeletal defects
- lung adenocarcinoma
- lung adenocarcinoma formation
- tremor
- growth failure
- rotator cuff injury
- streptozotocin induced type1 diabetes
role in cell
- exocytosis by
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- axon component
- cell surface
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lgi3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of exocytosis
- exocytosis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- synaptic vesicle
- juxtaparanode region of axon
- extracellular region