Adam23 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be active in glutamatergic synapse and presynaptic membrane. Orthologous to human ADAM23 (ADAM metallopeptidase domain 23). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adam23 |
| Official Name | ADAM metallopeptidase domain 23 [Source:RGD Symbol;Acc:1305739] |
| Ensembl ID | ENSRNOG00000012424 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase domain 23 |
| Synonyms | ADAM metallopeptidase domain 23, a disintegrin and metallopeptidase domain 23, AW046396, MDC-3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adam23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reprolysin family propeptide
- metallopeptidase
- ZnMc
- ADAM cysteine-rich
- peptidase
- integrin binding
- Disintegrin
- Reprolysin (M12B) family zinc metalloprotease
- protein binding
Pathways
Biological processes and signaling networks where the Adam23 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tonsillitis
- neoplasia
- immunodeficiency
- acute myeloid leukemia
- Parkinson disease
- ductal breast carcinoma
- ductal breast cancer
- growth failure
- upper respiratory tract disorder
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
regulates
role in cell
- production in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- Extracellular Space
- cellular membrane
- presynaptic membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adam23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- proteolysis
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- integrin binding
- metalloendopeptidase activity
- metallopeptidase activity