Adam22 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Involved in positive regulation of protein localization. Located in axon initial segment. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Orthologous to human ADAM22 (ADAM metallopeptidase domain 22). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adam22 |
| Official Name | ADAM metallopeptidase domain 22 [Source:RGD Symbol;Acc:1585016] |
| Ensembl ID | ENSRNOG00000042478 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase domain 22 |
| Synonyms | 2900022I03RIK, ADAM metallopeptidase domain 22, a disintegrin and metallopeptidase domain 22, DEE61, EIEE61, LOC108350662, LOC683655, MDC2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adam22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reprolysin family propeptide
- extracellular domain
- ZnMc
- ADAM cysteine-rich
- Metallo-peptidase family M12B Reprolysin-like
- ectodomain
- peptidase
- Disintegrin
- Reprolysin (M12B) family zinc metalloprotease
- protein binding
Pathways
Biological processes and signaling networks where the Adam22 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- early infantile epileptic encephalopathy type 61
- demyelination
- androgenic alopecia
- ataxia
- seizures
- toxic epidermal necrolysis
role in cell
- differentiation
- myelination in
- abnormal morphology
- clustering in
- myelination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- axon component
- cell surface
- cellular membrane
- synaptic membrane
- nerve ending
- axon initial segments
- juxtaparanodes
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adam22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- negative regulation of cell adhesion
- proteolysis
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- integrin binding
- metalloendopeptidase activity