Napepld Gene Summary [Rat]
Enables phospholipase activity. Involved in negative regulation of eating behavior; phospholipid metabolic process; and response to isolation stress. Predicted to be located in Golgi apparatus; early endosome; and nucleus. Predicted to be active in several cellular components, including hippocampal mossy fiber to CA3 synapse; smooth endoplasmic reticulum membrane; and synaptic membrane. Biomarker of osteoarthritis. Orthologous to human NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Napepld |
| Official Name | N-acyl phosphatidylethanolamine phospholipase D [Source:RGD Symbol;Acc:735197] |
| Ensembl ID | ENSRNOG00000011363 |
| Bio databases IDs | |
| Aliases | N-acyl phosphatidylethanolamine phospholipase D |
| Synonyms | A530089G06, C7orf18, FMP30, Mbldc1, N-acyl phosphatidylethanolamine phospholipase D |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Napepld often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta-lactamase superfamily domain
- Metallo-beta-lactamase superfamily
- binding protein
- zinc ion binding
- enzyme
- identical protein binding
- metallo-hydrolase-like_MBL-fold
- phosphoric diester hydrolase
- phospholipase
Pathways
Biological processes and signaling networks where the Napepld gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Cardiac β-adrenergic Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Endothelin-1 Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- G-Protein Coupled Receptor Signaling
- Gαq Signaling
- IL-8 Signaling
- mTOR Signaling
- Pancreatic Adenocarcinoma Signaling
- Protein Kinase A Signaling
- RAR Activation
- Relaxin Signaling
- Serotonin Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- lipid
- N-acylphosphatidylethanolamine
- N-palmitoylphosphatidylethanolamine
- palmitoylethanolamide
- N-acylethanolamine
- N-stearoylethanolamine
- N-stearoylphosphatidylethanolamine
- N-palmitoyl-lysophosphatidylethanolamine
- isolevuglandin-phosphatidylethanolamine
- phospholipid
disease
- breast carcinoma
- active ulcerative colitis
- hepatic fibrosis
- age-related hearing loss
phenotypes
- Huntington's Disease
- Spinal Cord Injuries
- Osteoarthritis
role in cell
- differentiation
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- presynaptic regions
- Nucleus
- Golgi Apparatus
- microsome
- presynaptic membrane
- postsynaptic membrane
- nucleoplasm
- nuclear envelope
- growth cone
- synapse
- photoreceptor outer segments
- early endosomes
- smooth endoplasmatic reticulum
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Napepld gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- N-acylphosphatidylethanolamine metabolic process
- retinoid metabolic process
- positive regulation of brown fat cell differentiation
- homeostasis of number of cells in a free-living population
- temperature homeostasis
- phospholipid catabolic process
- positive regulation of inflammatory response
- N-acylethanolamine metabolic process
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- nuclear envelope
- early endosome
- extracellular vesicular exosome
- cytoplasm
- Golgi membrane
- Golgi apparatus
- photoreceptor outer segment membrane
- membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- bile acid binding
- NAPE-specific phospholipase D activity