Clec4m

Predicted to enable several functions, including (1->3)-beta-D-glucan binding activity; D-mannose binding activity; and virus receptor activity. Predicted to be involved in immune response; receptor-mediated virion attachment to host cell; and symbiont entry into host cell. Predicted to act upstream of or within several processes, including detection of other organism; phagocytosis, recognition; and positive regulation of tumor necrosis factor production. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in extrapulmonary tuberculosis; pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CLEC4M (C-type lectin domain family 4 member M). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Clec4m often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.