Lrp3 Gene Summary [Rat]
Predicted to be involved in negative regulation of fat cell differentiation; positive regulation of osteoblast differentiation; and regulation of gene expression. Predicted to be located in clathrin-coated pit. Predicted to be active in plasma membrane. Orthologous to human LRP3 (LDL receptor related protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrp3 |
| Official Name | LDL receptor related protein 3 [Source:RGD Symbol;Acc:619729] |
| Ensembl ID | ENSRNOG00000011451 |
| Bio databases IDs | |
| Aliases | LDL receptor related protein 3 |
| Synonyms | LDL receptor related protein 3, low density lipoprotein receptor-related protein 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lrp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CUB
- cytoplasmic domain
- LDLa
- protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- squamous-cell carcinoma
- squamous cell cancer
- osteoarthritis
regulated by
- methylprednisolone
- polycystin
role in cell
- expression in
- phosphorylation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lrp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- positive regulation of gene expression
- negative regulation of fat cell differentiation
- positive regulation of osteoblast differentiation
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- coated pit
- membrane
- plasma membrane