Pld6 Gene Summary [Rat]
Predicted to enable RNA endonuclease activity, producing 5'-phosphomonoesters; cardiolipin hydrolase activity; and protein homodimerization activity. Predicted to be involved in several processes, including germ cell development; mitochondrial fusion; and piRNA processing. Predicted to act upstream of or within positive regulation of mitochondrial fusion. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Orthologous to human PLD6 (phospholipase D family member 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pld6 |
| Official Name | phospholipase D family, member 6 [Source:RGD Symbol;Acc:1311987] |
| Ensembl ID | ENSRNOG00000021657 |
| Bio databases IDs | |
| Aliases | phospholipase D family, member 6 |
| Synonyms | 4933433K01Rik, Gm10, mitoPLD, mZuc, phospholipase D family member 6, phospholipase D family, member 6, RGD1311987, ZUC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pld6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipase D
- protein homodimerization
- PLD-like domain
- enzyme
- protein binding
- Catalytic domain of phospholipase D superfamily proteins
- identical protein binding
- phosphoric diester hydrolase
- phospholipase
Pathways
Biological processes and signaling networks where the Pld6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Cardiac β-adrenergic Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Endothelin-1 Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- G-Protein Coupled Receptor Signaling
- Gαq Signaling
- IL-8 Signaling
- mTOR Signaling
- Pancreatic Adenocarcinoma Signaling
- Protein Kinase A Signaling
- RAR Activation
- Relaxin Signaling
- Serotonin Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- endoplasmic reticulum membrane
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pld6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic cell cycle
- spermatid development
- positive regulation of mitochondrial fusion
- mitochondrial fusion
- lipid catabolic process
- P granule organization
- piRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- Golgi apparatus
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- metal ion binding
- endoribonuclease activity, producing 5'-phosphomonoesters
- cardiolipin hydrolase activity